Jove
Visualize
Contact Us

Related Concept Videos

Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

376
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
376
The Behavioral Perspective on Personality01:19

The Behavioral Perspective on Personality

835
Behaviorists view personality as primarily shaped by environmental reinforcements and consequences. According to this perspective, behavior is influenced by external stimuli, and individuals adjust their actions based on rewards and punishments. Over time, learning histories — accumulated patterns of reinforcement — play a significant role in shaping personality. Behaviors that lead to positive outcomes are reinforced, while those resulting in negative outcomes are diminished.
835
Social Cognitive Perspective on Personality01:30

Social Cognitive Perspective on Personality

1.0K
Social cognitive perspectives on personality emphasize the importance of conscious awareness, beliefs, expectations, and goals in shaping behavior. These perspectives incorporate behaviorist principles, such as learning through reinforcement and conditioning, but extend beyond them by highlighting human reasoning and planning. Unlike traditional behaviorist views, social cognitive theory focuses on how individuals reflect on their past experiences and plan for future outcomes by considering...
1.0K
Phase-lead and Phase-lag Controllers01:22

Phase-lead and Phase-lag Controllers

574
Understanding the working function of different types of controllers can be illustrated with practical analogies, such as adjusting a stereo's volume equalizer. Cranking up the bass involves a phase-lead controller, which functions as a high-pass filter, while increasing the treble uses a phase-lag controller, which acts as a low-pass filter. PD controllers, similar to high-pass filters, enhance the system's response to high-frequency components. PI controllers, akin to low-pass...
574
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.7K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.

Bioorganic & medicinal chemistry letters·2023
Same author

Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.

Journal of medicinal chemistry·2023
Same author

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.

Journal of medicinal chemistry·2020
Same author

Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.

Bioorganic & medicinal chemistry letters·2018
Same author

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

Angewandte Chemie (International ed. in English)·2017
Same author

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).

Journal of medicinal chemistry·2017
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 7, 2026

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K

Lead-like Drugs: A Perspective.

Brian Raymer1, Samit K Bhattacharya1

  • 1Medicine Design , Pfizer Worldwide Research and Development , 1 Portland Street , Cambridge , Massachusetts 02139 , United States.

Journal of Medicinal Chemistry
|July 28, 2018
PubMed
Summary
This summary is machine-generated.

Lead-like drugs, under 300 molecular weight, are vital in drug discovery. Optimizing medicinal chemistry for low molecular weight starting points can enhance the discovery rate of these important compounds.

More Related Videos

Electrocardiogram Recordings in Anesthetized Mice using Lead II
04:16

Electrocardiogram Recordings in Anesthetized Mice using Lead II

Published on: June 20, 2020

14.3K
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.2K

Related Experiment Videos

Last Updated: Feb 7, 2026

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K
Electrocardiogram Recordings in Anesthetized Mice using Lead II
04:16

Electrocardiogram Recordings in Anesthetized Mice using Lead II

Published on: June 20, 2020

14.3K
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.2K

Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Pharmacology

Background:

  • Lead-like drugs (MW < 300) are crucial yet often overlooked in modern drug development.
  • Contemporary medicinal chemistry emphasizes the strategic use of low molecular weight compounds.

Purpose of the Study:

  • To assess the current landscape of lead-like drug discovery.
  • To analyze recent trends in drug approvals and prescriptions concerning lead-like compounds.

Main Methods:

  • Surveyed drug approvals from 2011-2017 and the top 200 prescribed medications.
  • Conducted case studies on recently approved lead-like drugs.
  • Analyzed medicinal chemistry optimization strategies focusing on low molecular weight.

Main Results:

  • Many recent lead-like drugs are analogs of existing drugs or natural substrates.
  • Medicinal chemistry optimization prioritizes low molecular weight starting points and their maintenance.
  • Identification of suitable low molecular weight starting points may be hindered by screening library limitations.

Conclusions:

  • Increasing the discovery rate of lead-like drugs requires a greater focus on lead-like starting points in screening libraries.
  • Enhanced inclusion and prosecution of lead-like starting points in screening sets are recommended.
  • Strategic library design can boost the identification of novel lead-like therapeutics.