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HDncRNA: a comprehensive database of non-coding RNAs associated with heart diseases.
Wen-Jing Wang1,2,3, Yu-Mei Wang1,2,3, Yi Hu1,2,3
1Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, No. 150, Jimo Road, Pudong New District, Shanghai, China.
Summary
A new database, HDncRNA, systematically curates associations between heart diseases (HDs) and non-coding RNAs (ncRNAs). It offers a valuable resource for researchers studying the complex roles of ncRNAs in cardiovascular health and disease.
Area of Science:
- Cardiovascular Biology
- Genomics
- Bioinformatics
Background:
- Heart diseases (HDs) are a major cause of morbidity and mortality.
- Non-coding RNAs (ncRNAs) are increasingly recognized for their critical roles in HDs.
- A systematic investigation of HDs-ncRNA associations is currently lacking.
Purpose of the Study:
- To develop a comprehensive database (HDncRNA) for curated HDs-ncRNA associations.
- To provide a centralized resource for exploring ncRNAs involved in heart diseases.
- To facilitate research into the mechanisms of ncRNAs in cardiovascular pathology.
Main Methods:
- Curated data from 1904 articles, 3 databases (HMDD, miR2disease, lncRNAdisease), and 5 RNA-seq datasets.
- Classified associations into 'direct evidence', 'high-throughput associations', and 'predicted associations' based on validation.
- Integrated data across 6 species, including human, mouse, and rat.
Main Results:
- The HDncRNA database contains 2304 HDs-ncRNA associations for 133 HDs.
- Includes a user-friendly web interface, visualization tools for genomic locations, and links to external databases.
- Provides information on neighboring genes for lncRNAs.
Conclusions:
- HDncRNA serves as an excellent platform for exploring heart disease-related ncRNAs.
- Facilitates deeper understanding of ncRNA functions in cardiovascular diseases.
- Supports the discovery of novel diagnostic and therapeutic targets for HDs.
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