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Lectins as antimicrobial agents.

L C Breitenbach Barroso Coelho1, P Marcelino Dos Santos Silva1, W Felix de Oliveira1

  • 1Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil.

Journal of Applied Microbiology
|July 28, 2018
PubMed
Summary
This summary is machine-generated.

Lectins, natural proteins that bind to microbial carbohydrates, show promise as antimicrobials. Their oligomerization and binding mechanisms offer new strategies against resistant infections in humans and animals.

Keywords:
antimicrobialsbiofilmslectin-based therapieslectinsmicro-organism infectionsquorum sensing

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Area of Science:

  • Biochemistry and Molecular Biology
  • Microbiology
  • Drug Discovery

Background:

  • Microbial resistance to antimicrobial agents presents a significant challenge in treating infections and for environmental control.
  • Lectins are carbohydrate-binding proteins with potential antimicrobial properties.

Purpose of the Study:

  • To review and evaluate lectins as a potential antimicrobial strategy.
  • To explore the mechanisms of lectin-mediated antimicrobial activity.
  • To discuss the role of lectin oligomerization in biological activity and binding capacity.

Main Methods:

  • Literature review of scientific articles on lectins and their antimicrobial properties.
  • Analysis of lectin mechanisms, including carbohydrate binding, pore formation, and cell wall interactions.
  • Evaluation of antiquorum-sensing therapies involving lectins.

Main Results:

  • Lectins exhibit antimicrobial activity through various mechanisms, including pore formation and cell wall disruption.
  • Antifungal activity is linked to chitin-binding properties, leading to cell wall disintegration or inhibited synthesis.
  • Lectins show potential in antiquorum-sensing therapies against microbial virulence factors.

Conclusions:

  • Lectins represent a promising class of natural antimicrobials with diverse mechanisms of action.
  • Understanding lectin oligomerization and binding dynamics is crucial for optimizing their antimicrobial efficacy.
  • Lectins offer a potential alternative or complementary approach to combatting antimicrobial resistance.