Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

2.4K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.4K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

14.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
14.8K
Structure and Function of Platelets01:18

Structure and Function of Platelets

3.6K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.6K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

9.3K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting nuclear export and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling in myelofibrosis: A novel combinatorial strategy that impacts intrinsic and microenvironment-related pathways.

British journal of haematology·2026
Same author

Menin-dependent megakaryocyte proliferation and fibrosis in myeloproliferative neoplasms.

Cancer cell·2026
Same author

Linezolid Acts as a Selective Inhibitor of the JAK2 <sup>V617F</sup> Mutation.

bioRxiv : the preprint server for biology·2026
Same author

Long term outcomes of idasanutlin therapy in hydroxyurea-refractory polycythemia vera patients.

Leukemia & lymphoma·2026
Same author

Inhibition of the EBF1-ITGB8 Axis in Bone Marrow Niche Ameliorates Hallmarks of Myelofibrosis.

bioRxiv : the preprint server for biology·2026
Same author

Wnt-dependent spatiotemporal reprogramming of bone marrow niches drives fibrosis.

HemaSphere·2026

Related Experiment Video

Updated: Feb 7, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

16.6K

Whirling Platelets Away for Transfusion.

Camelia Iancu-Rubin1, Ronald Hoffman1, Anna Rita Migliaccio2

  • 1Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.

Cell
|July 28, 2018
PubMed
Summary

Researchers discovered that turbulence regulates platelet production in vivo. This finding can be used in bioreactors for large-scale, clinical production of functional platelets from human induced pluripotent stem cells (iPSCs).

More Related Videos

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.4K
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.0K

Related Experiment Videos

Last Updated: Feb 7, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

16.6K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.4K
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.0K

Area of Science:

  • Biotechnology
  • Hematology
  • Regenerative Medicine

Background:

  • Platelet transfusions are crucial for treating various medical conditions.
  • Current platelet supply relies heavily on human donors, posing challenges for meeting growing demand.
  • Large-scale ex vivo platelet production is needed to ensure a sufficient and reliable supply.

Purpose of the Study:

  • To investigate the physical regulators of platelet generation in vivo.
  • To explore the potential of exploiting these regulators for clinical-scale platelet production.
  • To develop a method for generating functional platelets from human induced pluripotent stem cells (iPSCs).

Main Methods:

  • Investigated the role of physical forces, specifically turbulence, in megakaryopoiesis and platelet release in vivo.
  • Developed a bioreactor system designed to mimic physiological turbulence.
  • Utilized human induced pluripotent stem cells (iPSCs) as the starting material for platelet generation.

Main Results:

  • Identified turbulence as a key physical regulator of platelet formation in vivo.
  • Demonstrated that controlled turbulence in a bioreactor promotes efficient platelet generation from iPSCs.
  • Produced functional platelets at a scale suitable for clinical applications.

Conclusions:

  • Turbulence is a critical factor in natural platelet production.
  • Bioreactor-based production leveraging turbulence offers a promising strategy for meeting the demand for transfusable platelets.
  • This approach could reduce reliance on donor screening and enhance the availability of platelets for patients.