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Related Concept Videos

Schemas01:42

Schemas

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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
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Spondylitis - Spondylodiscitis - an Update.

Rahel Bornemann1, Philip Rössler1, Cornelius Jacobs1

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Zeitschrift Fur Orthopadie Und Unfallchirurgie
|July 28, 2018
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This summary is machine-generated.

Spondylodiscitis, a spinal infection, is best diagnosed using MRI and 16S rRNA PCR on tissue samples. Treatment involves targeted antibiotics and potentially surgery for severe cases, with good prognosis when infection markers decrease.

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Area of Science:

  • Infectious Diseases
  • Orthopedic Surgery
  • Radiology

Background:

  • Spondylodiscitis involves infection of the intervertebral disc and adjacent vertebrae.
  • Common causes include bacteria (Staphylococcus aureus, tuberculosis), fungi, and parasites.
  • Staphylococcus aureus is the most frequent cause of pyogenic spondylodiscitis.

Purpose of the Study:

  • To review diagnostic methods for spondylodiscitis.
  • To outline current treatment strategies, including antibiotic therapy and surgical interventions.
  • To discuss factors influencing prognosis.

Main Methods:

  • Review of diagnostic modalities: MRI, blood cultures, histological examination, and 16S rRNA PCR.
  • Analysis of treatment approaches: intravenous and oral antibiotic regimens, and surgical indications.
  • Evaluation of prognostic indicators such as CRP and ESR reduction.

Main Results:

  • MRI demonstrates high sensitivity and specificity for diagnosis.
  • 16S rRNA PCR on tissue samples is superior to traditional microbiological methods for pathogen detection.
  • Standardized antibiotic therapy is not well-defined; pathogen-specific, focused treatment is crucial.

Conclusions:

  • Early and accurate diagnosis via advanced imaging and molecular techniques is vital.
  • Treatment requires tailored antibiotic therapy, with surgery indicated for neurological deficits or treatment failure.
  • Prognosis is favorable with effective infection control, evidenced by reduced inflammatory markers.