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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-III: Symptoms and Complications01:24

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
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Related Experiment Video

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Acupuncture in a Rat Model of Asthma
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Pediatric rhinosinusitis and asthma.

Dimitri Poddighe1, Ilaria Brambilla2, Amelia Licari2

  • 1Department of Medicine, Nazarbayev University School of Medicine, Astana, Kazakhstan; Department of Pediatrics, Università Degli Studi, Pavia, Italy.

Respiratory Medicine
|July 29, 2018
PubMed
Summary
This summary is machine-generated.

Pediatric asthma and rhinosinusitis frequently coexist, impacting 35-65% of children. This review explores the shared pathophysiology, revealing how upper airway inflammation can systemically amplify lower airway eosinophilic responses.

Keywords:
AsthmaBasophilEosinophilIL-5Nasal polyposisRhinosinusitis

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Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Otolaryngology

Background:

  • Asthma and rhinosinusitis are complex, heterogeneous diseases frequently co-occurring in children.
  • This comorbidity affects an estimated 35-65% of pediatric patients, necessitating clinical attention.
  • Understanding the link between upper and lower airway diseases is crucial for effective management.

Purpose of the Study:

  • To review the pathophysiological mechanisms linking rhinosinusitis and asthma in children.
  • To elucidate the complex interplay between upper and lower airway inflammation.
  • To highlight the systemic amplification of eosinophilic inflammation.

Main Methods:

  • Literature review focusing on pediatric studies.
  • Analysis of pathophysiological pathways connecting rhinosinusitis and asthma.
  • Examination of inflammatory processes, including cytokine release and bone marrow stimulation.

Main Results:

  • Rhinosinusitis can exacerbate asthma via contiguous mechanisms.
  • A persistent Th2-driven, eosinophilic inflammatory process in one airway site can trigger systemic effects.
  • Cytokines released into the bloodstream stimulate bone marrow, amplifying eosinophilic inflammation.

Conclusions:

  • The comorbidity of asthma and rhinosinusitis involves a complex interplay beyond simple contiguity.
  • Systemic amplification of eosinophilic inflammation, originating from upper airway disease, plays a significant role.
  • Further research into this systemic link is paramount for pediatric respiratory health.