Related Experiment Video
Updated: Feb 7, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
Nicotine absorption from e-cigarettes over 12 months.
K Soar1, C Kimber2, H McRobbie3
1University of East London, United Kingdom.
Experienced vapers reduce nicotine concentration in e-liquids but increase consumption, maintaining nicotine levels. This suggests reduced nicotine e-liquid may not lower intake and could increase costs.
Area of Science:
- Tobacco and Nicotine Research
- Public Health
Background:
- Exclusive e-cigarette users (vapers) often decrease nicotine concentration over time.
- Vapers may transition to advanced devices and increase e-liquid consumption while maintaining nicotine levels.
Purpose of the Study:
- To confirm if experienced vapers reduce nicotine concentration and alter consumption patterns over 12 months.
- To measure nicotine absorption, e-liquid concentration, consumption volume, and device/flavor preferences.
Main Methods:
- Longitudinal study of 27 experienced vapers over 12 months.
- Measured salivary cotinine (nicotine metabolite), e-liquid nicotine concentration, and consumption volume.
- Assessed device types and flavors used at baseline and follow-up.
Main Results:
- Nicotine e-liquid concentration decreased from 13.83 to 9.91 mg/mL over 12 months.
- E-liquid consumption significantly increased from 4.44 to 6.84 mL/day.
- Salivary cotinine levels showed no significant change, indicating stable nicotine absorption.
Conclusions:
- Experienced vapers reduce nicotine concentration but maintain intake, possibly through increased puffing intensity (self-titration).
- Reducing nicotine e-liquid concentration may lead to higher consumption, potentially increasing health and financial costs.
- Further research is needed to understand motivations for lowering e-liquid nicotine concentration.
More Related Videos
10:44Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
09:30A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
Related Concept Videos
Cholinergic Receptors: Nicotinic
There are two types of nicotinic receptors: neuromuscular (NM/NM/N1) and neuronal (NN/NN/N2). The two families differ based on their location and selectivity to...
CNS Depressants: Alcohol and Nicotine
Drug Absorption: Factors Affecting GI Absorption
Absorption of Radiation
Protein Absorption
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...