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Nicotine absorption from e-cigarettes over 12 months.

K Soar1, C Kimber2, H McRobbie3

  • 1University of East London, United Kingdom.

Addictive Behaviors
|July 29, 2018
PubMed
Summary
This summary is machine-generated.

Experienced vapers reduce nicotine concentration in e-liquids but increase consumption, maintaining nicotine levels. This suggests reduced nicotine e-liquid may not lower intake and could increase costs.

Keywords:
CotinineE-cigarettesNicotine absorptionNicotine concentrationsTitrationVapers

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Area of Science:

  • Tobacco and Nicotine Research
  • Public Health

Background:

  • Exclusive e-cigarette users (vapers) often decrease nicotine concentration over time.
  • Vapers may transition to advanced devices and increase e-liquid consumption while maintaining nicotine levels.

Purpose of the Study:

  • To confirm if experienced vapers reduce nicotine concentration and alter consumption patterns over 12 months.
  • To measure nicotine absorption, e-liquid concentration, consumption volume, and device/flavor preferences.

Main Methods:

  • Longitudinal study of 27 experienced vapers over 12 months.
  • Measured salivary cotinine (nicotine metabolite), e-liquid nicotine concentration, and consumption volume.
  • Assessed device types and flavors used at baseline and follow-up.

Main Results:

  • Nicotine e-liquid concentration decreased from 13.83 to 9.91 mg/mL over 12 months.
  • E-liquid consumption significantly increased from 4.44 to 6.84 mL/day.
  • Salivary cotinine levels showed no significant change, indicating stable nicotine absorption.

Conclusions:

  • Experienced vapers reduce nicotine concentration but maintain intake, possibly through increased puffing intensity (self-titration).
  • Reducing nicotine e-liquid concentration may lead to higher consumption, potentially increasing health and financial costs.
  • Further research is needed to understand motivations for lowering e-liquid nicotine concentration.