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Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

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Anti-tumor necrosis factor agents in Crohn's disease and ulcerative colitis: Beyond luminal disease

Laura Núñez-Gómez1, Francisco Mesonero-Gismero1, Agustín Albillos-Martínez1

  • 1Servicio de Gastroenterología y Hepatología, Hospital Universitario Ramón y Cajal, Madrid, España.

Gastroenterologia Y Hepatologia
|July 29, 2018
PubMed

Anti-tumor necrosis factor agents (anti-TNF) drugs are commonly used in patients with inflammatory bowel disease (IBD) and have proven effective in both induction and maintenance therapy in luminal Crohn's disease and ulcerative colitis. Their efficacy has also been proven in fistulising perianal Crohn's disease. However, the evidence in other scenarios, such as stricturing, penetrating and non-fistulising perianal Crohn's disease, extraintestinal IBD manifestations and ileoanal reservoir complications, is not as robust. The aim of this review was to perform an analysis of the available literature and to determine the role of anti-TNF drugs in common clinical practice in patients affected by these complications.

Keywords:
Anti-TNFColitis ulcerosaCrohn's diseaseEnfermedad de CrohnEnfermedad inflamatoria intestinalInflammatory bowel diseaseUlcerative colitis

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