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Intracortical Microstimulation Modulates Cortical Induced Responses.

Mathias Benjamin Voigt1,2, Prasandhya Astagiri Yusuf3,2,4, Andrej Kral3,2

  • 1Institute of AudioNeuroTechnology and Department of Experimental Otology, Hannover Medical School, 30625 Hannover, Germany, voigt.mathias@mh-hannover.de.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 29, 2018
PubMed
Summary

Low-current intracortical microstimulation (ICMS) enhances auditory cortex responses to sensory stimuli by integrating with, not replacing, ongoing neural activity. This suggests a new approach for brain prosthetics.

Keywords:
auditory cortexcortical implanthearingneuroprostheticoscillation

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Auditory Neuroscience

Background:

  • Cortical prosthetics often use intracortical microstimulation (ICMS) to activate neural networks.
  • Existing methods may not consider the brain's ongoing activity during stimulation.

Purpose of the Study:

  • To investigate how low-current ICMS affects sensory processing in the primary auditory cortex (A1).
  • To determine if ICMS integrates with or substitutes ongoing cortical activity.

Main Methods:

  • Extracellular potentials were recorded from the auditory cortex of anesthetized guinea pigs.
  • Time-frequency analyses were used to examine evoked and induced neural activity.
  • Low-current ICMS was applied during acoustic stimulation.

Main Results:

  • ICMS enhanced the long-latency induced component of the auditory response.
  • The phase of the local field potential predicted response amplitude for acoustic, ICMS, and combined stimuli.
  • ICMS response was integrated into, rather than substituting, ongoing cortical processes.

Conclusions:

  • Low-current ICMS can modulate sensory processing in the auditory cortex.
  • This modulation mimics natural top-down feedback mechanisms.
  • Targeted modulation offers a promising alternative for developing cortical prostheses.