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Updated: Feb 7, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE
Published on: May 31, 2013
High-throughput determination of RNA structures
Eric J Strobel1, Angela M Yu2, Julius B Lucks3
1Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.
Abstract:
RNA performs and regulates a diverse range of cellular processes, with new functional roles being uncovered at a rapid pace. Interest is growing in how these functions are linked to RNA structures that form in the complex cellular environment. A growing suite of technologies that use advances in RNA structural probes, high-throughput sequencing and new computational approaches to interrogate RNA structure at unprecedented throughput are beginning to provide insights into RNA structures at new spatial, temporal and cellular scales.
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