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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
Published on: October 13, 2018
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Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man.
Robert J Fenster1, Lauren A M Lebois1, Kerry J Ressler2
1Division of Depression and Anxiety Disorders, McLean Hospital Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.
Nature Reviews. Neuroscience
|July 29, 2018
Summary
New brain imaging technologies enhance understanding of post-traumatic stress disorder (PTSD) mechanisms. This offers promising avenues for developing novel interventions and treatments for this debilitating condition.
Area of Science:
- Neuroscience
- Psychiatry
- Trauma Studies
Background:
- Post-traumatic stress disorder (PTSD) is a significant public health concern, resulting from severe psychological trauma.
- Current treatments for PTSD are limited in efficacy for many individuals.
- There is a critical need for innovative interventions, treatments, and preventative strategies for PTSD.
Purpose of the Study:
- To explore recent advancements in understanding the neurobiological underpinnings of PTSD.
- To highlight how technological innovations have facilitated a deeper insight into PTSD-related brain circuits.
- To identify promising directions for future therapeutic development in PTSD.
Main Methods:
- Utilized technological revolutions enabling observation and perturbation of brain circuits.
- Focused on macrocircuits and microcircuits implicated in PTSD symptoms.
- Integrated translational research approaches to PTSD.
Main Results:
- Gained a more translational understanding of PTSD pathophysiology.
- Achieved enhanced insights into the mechanisms contributing to PTSD risk and resilience.
- Identified novel avenues for therapeutic discovery in PTSD.
Conclusions:
- Recent technological advancements have significantly improved our understanding of PTSD brain circuitry.
- These insights provide a foundation for developing more effective PTSD treatments.
- Further research into neural circuits holds promise for addressing the unmet needs in PTSD intervention.
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