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Updated: Feb 7, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
Published on: October 2, 2019
Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation
Daniel G Almeida-Filho1, Claudio M Queiroz1, Sidarta Ribeiro2
1Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, 59056-450, Brazil.
Abstract:
Once viewed as a passive physiological state, sleep is a heterogeneous and complex sequence of brain states with essential effects on synaptic plasticity and neuronal functioning. Rapid-eye-movement (REM) sleep has been shown to promote calcium-dependent plasticity in principal neurons of the cerebral cortex, both during memory consolidation in adults and during post-natal development. This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories. The body of evidence suggests that memory corticalization triggered by REM sleep is a systemic phenomenon with cellular and molecular causes.
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