Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A case of intrascrotal hemangioma].

Hinyokika kiyo. Acta urologica Japonica·1992
Same author

Chromosome-sized DNA of Malassezia pachydermatis by pulsed-field gel electrophoresis.

The Journal of veterinary medical science·1992
Same author

Plasma thrombomodulin and alpha 2-plasmin inhibitor-plasmin complex are elevated in active systemic lupus erythematosus.

The Journal of rheumatology·1992
Same author

Effect of prolyl 4-hydroxylase inhibitor on fibroblast collagen production in vitro: an approach to the treatment of systemic sclerosis.

The Journal of rheumatology·1992
Same author

Unilateral dermatomal pigmentary dermatosis: a variant dyschromatosis?

Journal of the American Academy of Dermatology·1992
Same author

Delayed shortening and shrinkage of cochlear outer hair cells.

The American journal of physiology·1992

Related Experiment Video

Updated: Jan 13, 2026

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
08:00

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Published on: June 4, 2020

3.9K

Microscopic globular bodies in the human brain.

M Hara

    Journal of Neuropathology and Experimental Neurology
    |March 1, 1986
    PubMed
    Summary

    Microscopic globular bodies (MGB) are novel brain structures found in gray matter. Their numbers correlate with age and decrease in neurological disorders associated with cognitive decline.

    Area of Science:

    • Neuroscience
    • Neuropathology
    • Cell Biology

    Background:

    • Microscopic globular bodies (MGB) are distinct from corpora amylacea, axonal spheroids, and Hirano bodies.
    • MGB are eosinophilic, 1-10 micron globular structures found in the gray matter neuropil, primarily the cerebral cortex.

    Purpose of the Study:

    • To characterize the ultrastructural features of MGB.
    • To investigate the quantitative relationship between MGB and age.
    • To explore the association of MGB with neurological disorders.

    Main Methods:

    • Histological staining (H&E) and ultrastructural analysis (electron microscopy).
    • Quantitative assessment of MGB numbers in relation to age and neurological conditions.

    Main Results:

    More Related Videos

    Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
    08:29

    Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

    Published on: December 18, 2016

    14.5K
    An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
    07:45

    An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

    Published on: October 21, 2014

    8.3K

    Related Experiment Videos

    Last Updated: Jan 13, 2026

    Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
    08:00

    Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

    Published on: June 4, 2020

    3.9K
    Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
    08:29

    Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

    Published on: December 18, 2016

    14.5K
    An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
    07:45

    An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

    Published on: October 21, 2014

    8.3K
    • Ultrastructurally, MGB are osmiophilic, homogeneous, finely granular, and enclosed by a ruffled membrane within cytoplasmic processes.
    • MGB presence shows a strong positive correlation with increasing age.
    • Fewer MGB were observed in neurological disorders characterized by mental retardation or dementia.

    Conclusions:

    • MGB represent a unique cellular structure in the brain neuropil.
    • MGB accumulation is age-dependent and may serve as a biomarker for cognitive health.
    • Further research is needed to elucidate the precise function and origin of MGB.