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Updated: Feb 7, 2026

Developing a Behavioral Box for Assessing Prepulse Inhibition and Neural Activity in Psychiatric Animal Models
Published on: July 22, 2025
Deficits of perceived spatial separation-induced prepulse inhibition in patients with bipolar disorder compared to
Qijing Bo1, Zhen Mao1, Qing Tian1
1The National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Objective:
This study aimed to assess sensorimotor gating deficits in patients with bipolar disorder (BD) using a modified perceived spatial separation-induced prepulse inhibition (PSS-PPI) paradigm. The relationships between PSS-PPI, demographic and clinical characteristics, and cognitive functioning were also analyzed.
Methods:
In this cross-sectional study, 30 patients with BD were compared to 33 healthy controls (HC) with respect to prepulse inhibition measures of PSS-PPI using a 120 ms lead interval. The Young Mania Rating Scale, Hamilton Depression Scale, and Hamilton Anxiety Scale were used to assess manic, depressive, and anxiety symptoms. Cognition was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Stroop color-word test.
Results:
Compared with HC, patients with BD had a lower PSS-PPI level. PSS-PPI showed medium effect size (ES) between patients with BD and HC (ES = 0.65). Among patients with BD, PSS-PPI was positively correlated with the language domain of RBANS and negatively correlated with double word time and color interference time. There were no differences in PSS-PPI levels between patients with and without psychotic symptoms or between those euthymic patients or depressive patients with BD.
Conclusions:
Patients with BD show a sensorimotor gating deficit as measured by perceived spatial separation-induced PPI of the startle response, which was more sensitive compared to the classic PPI paradigm. Euthymic bipolar patients and depressive bipolar patients show similar PPI level. PPI deficit in patients with BD is related to cognition, but not with demographic and clinical characteristics.
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