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Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide
Rahmet Parilti1, Raphaël Riva2, Steven M Howdle3
1CERM, CESAM Research Unit, University of Liege, 13, Allee du Six Août, B-4000 Liege, Belgium; School of Chemistry, University of Nottingham, University Park, NG7 2RD Nottingham, United Kingdom.
Abstract:
Sulindac loaded poly(HEMA) cross-linked microparticles were synthesized via one-pot free-radical dispersion polymerisation in supercritical carbon dioxide (scCO2) in presence of photocleavable diblock stabilisers based on polyethylene oxide (PEO) and poly(heptadecafluorodecyl acrylate) (PFDA) bearing a o-nitrobenzyl photosensitive junction (hv) (PEO-hv-PFDA), and ethylene glycol dimethacrylate (EGDMA) as cross-linker. Poly(HEMA) cross-linked microparticles either empty or sulindac loaded were obtained with well-defined spherical morphology with the sizes between 250 and 350 nm. Additionally, upon UV-photolysis the stabiliser on the surface was cleaved which permits to microparticles to be redispersed in water leading to water swollen microgels about 2.1-3.6 µm. Moreover, the release behaviour from obtained microgels indicated the sustained release of sulindac over 10 days. Besides, the surface modification after UV-photolysis was studied and proved that the particles can be functionalised with further chemistries.
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