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Standardization in host-microbiota interaction studies: challenges, gnotobiology as a tool, and perspective
Catherine Mooser1, Mercedes Gomez de Agüero1, Stephanie C Ganal-Vonarburg1
1Universitätsklinik für Viszerale Chirurgie und Medizin, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Current Opinion in Microbiology
|July 30, 2018
Summary
Gnotobiotic mice with defined microbial communities are essential for studying host-microbe interactions. Standardized gnotobiology research ensures reliable and reproducible results for advancing biomedical science.
Area of Science:
- Microbiology
- Immunology
- Host-Microbe Interactions
Background:
- Growing evidence links commensal microbiota to various diseases.
- Understanding host-microbe interactions is crucial for biomedical research.
- Axenic and colonized animal models are key tools for these studies.
Purpose of the Study:
- To highlight recent advances in gnotobiology.
- To discuss challenges and future goals in the field.
- To promote reliable and reproducible research in host-microbe interactions.
Main Methods:
- Utilizing gnotobiotic mice with defined microbial communities.
- Implementing housing standardization for experimental consistency.
- Controlling for confounding factors like host genetics, diet, and antibiotics.
Main Results:
- Gnotobiotic models with defined microbiotas are a gold standard for studying microbiome influence.
- Standardization enhances the reliability and transferability of experimental results.
- Advances in gnotobiology facilitate a deeper understanding of host-microbe dynamics.
Conclusions:
- Gnotobiology is vital for dissecting host-microbe interactions.
- Standardized gnotobiotic research is essential for reproducible biomedical findings.
- Future goals include overcoming challenges to further advance the field.
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