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Endocrine therapy for ER-positive/HER2-negative metastatic breast cancer

Tomás Reinert1, Bruno de Paula2, Maryam Nemati Shafaee3

  • 1Hospital do Câncer Mãe de Deus, Porto Alegre, Brazil; Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Chinese Clinical Oncology
|July 31, 2018
PubMed

Insights

Estrogen receptor (ER)-positive breast cancer treatment faces challenges despite effective therapies. Ongoing research aims to overcome resistance and optimize treatment strategies for better patient outcomes.

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Estrogen receptor (ER)-positive breast cancer is the most common subtype.
  • ER-directed therapies improve survival and symptoms in advanced disease with a favorable side effect profile.
  • Despite advances, ER-positive advanced breast cancer remains incurable, highlighting the need for improved strategies.

Purpose of the Study:

  • To review current challenges and ongoing efforts in treating ER-positive breast cancer.
  • To discuss strategies for overcoming endocrine resistance.
  • To address the optimal selection and sequencing of therapies for advanced ER+ breast cancer.

Main Methods:

  • Review of existing literature on ER-positive breast cancer treatment.
  • Analysis of current therapeutic strategies, including endocrine agents and combination therapies.
  • Discussion of emerging approaches to circumvent resistance mechanisms.

Main Results:

  • ER-directed therapies are effective but resistance remains a significant clinical challenge.
  • Combination therapies targeting ER and other signaling pathways are being integrated into practice.
  • Key questions persist regarding optimal treatment selection, sequencing, and patient benefit maximization.

Conclusions:

  • Despite a century of targeting the estrogen receptor, significant challenges persist in treating ER-positive breast cancer.
  • Overcoming resistance mechanisms and optimizing therapeutic sequencing are critical for improving outcomes.
  • Further research is needed to extend the benefits of advanced breast cancer therapies to more patients.
Keywords:
Advanced breast cancerbreast neoplasmdrug resistanceendocrine therapy (ET)estrogen receptor (ER)

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