Related Experiment Video

Updated: Feb 7, 2026

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

799

Management of breast cancer brain metastases

Hideaki Takahashi1, Mizuho Isogawa2

  • 1Section of Neurosurgery, Niigata Cancer Center Hospital, Niigata, Japan. takahasi@niigata-cc.jp.

Chinese Clinical Oncology
|July 31, 2018
PubMed

Insights

Brain metastases in breast cancer patients often have a poor prognosis. This review discusses current neurological management strategies and therapeutic decisions for breast cancer brain metastases (BCBMs), considering subtype and presentation.

Area of Science:

  • Oncology
  • Neurology
  • Radiology

Background:

  • Brain metastases are a common complication of breast cancer, associated with poor prognosis and limited treatment options.
  • Current treatments for breast cancer brain metastases (BCBMs) primarily involve local therapies like surgery or radiotherapy.
  • The efficacy of targeted therapies like epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in EGFR-mutation-positive non-small cell lung cancer brain metastases highlights a potential area for investigation in breast cancer.

Purpose of the Study:

  • To review the neurological management and therapeutic decision-making process for breast cancer brain metastases (BCBMs).
  • To emphasize the importance of considering breast cancer subtype and the diverse presentations of BCBMs in treatment planning.
  • To provide insights into early diagnosis and individualized therapeutic approaches for BCBMs.

Main Methods:

  • Literature review focusing on neurological management and therapeutic strategies for BCBMs.
  • Analysis of the association between breast cancer subtypes and the incidence/prognosis of brain metastases.
  • Inclusion of representative MRI images illustrating various forms of BCBMs.

Main Results:

  • Breast cancer subtypes influence the occurrence and prognosis of brain metastases.
  • BCBMs present in various forms, including brain parenchymal metastases, leptomeningeal carcinomatoses, and intracranial dural metastases.
  • Effective management requires early diagnosis and tailored therapeutic strategies based on individual patient factors.

Conclusions:

  • Optimal management of BCBMs necessitates a comprehensive approach considering the specific breast cancer subtype and metastatic pattern.
  • Individualized treatment plans are crucial for stabilizing neurological function, palliating symptoms, and improving patient outcomes.
  • Further research into targeted therapies, drawing parallels from other cancer types, may offer new avenues for BCBM treatment.
Keywords:
Breast cancer brain metastasis (BCBM)brain parenchymal metastasis (BPM)intracranial dural metastasis (IDM)leptomeningeal carcinomatosis (LMC)

More Related Videos

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells05:02

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

3.8K
Ultrasound Imaging-guided Intracardiac Injection to Develop a Mouse Model of Breast Cancer Brain Metastases Followed by Longitudinal MRI08:36

Ultrasound Imaging-guided Intracardiac Injection to Develop a Mouse Model of Breast Cancer Brain Metastases Followed by Longitudinal MRI

Published on: March 6, 2014

19.7K

Related Concept Videos

Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
438
Impression Management Techniques I: Managing Appearances01:29

Impression Management Techniques I: Managing Appearances

Appearance is a multidimensional aspect of self-presentation that encompasses observable attributes such as clothing, grooming, speech, and nonverbal behavior. These elements are often strategically managed to align with socially constructed expectations in different settings. For instance, individuals tailor their appearance during job interviews, social gatherings, or athletic events to meet the perceived norms of those environments.Contextual Adaptation and Social SignalsThe research...
220
Managing Impressions01:19

Managing Impressions

Impression management encompasses individuals' deliberate efforts to shape how others perceive them during social interactions. This behavior is often employed to conform to social norms, secure approval, or pursue specific goals. While it involves selective self-presentation, it is not necessarily deceptive; individuals frequently present authentic aspects of themselves that align with situational demands.Common strategies include:Ingratiation: where individuals use flattery or agreeableness...
173
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
657
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
545
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
297