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Updated: Feb 7, 2026

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

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Advances in treatment of metastatic breast cancer with bone metastasis

Ziping Wu1, Jinsong Lu2

  • 1Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Chinese Clinical Oncology
|July 31, 2018
PubMed

Insights

Metastatic breast cancer commonly affects bone. Current treatments include bone-targeting drugs like bisphosphonates and denosumab, with ongoing research into optimal use and new therapies.

Area of Science:

  • Oncology
  • Bone Metastasis Research
  • Pharmacology

Background:

  • Bone is the most frequent site for metastatic breast cancer (MBC).
  • Treatment strategies involve systemic therapy tailored to molecular subtypes and specific bone interventions.
  • Current approved bone-targeting agents include bisphosphonates and denosumab.

Purpose of the Study:

  • To review current treatment approaches for bone metastases in breast cancer.
  • To highlight the limitations and ongoing research regarding bisphosphonate and denosumab dosing and duration.
  • To introduce emerging therapies for bone metastatic breast cancer.

Main Methods:

  • Literature review of current treatment guidelines and clinical trials.
  • Analysis of approved therapies for bone metastases.
  • Exploration of novel therapeutic agents in preclinical or early clinical development.

Main Results:

  • Bisphosphonates and denosumab are the primary approved treatments for bone metastases.
  • Optimal dosing schedules and treatment durations for these agents remain subjects of active research.
  • Several novel therapeutic avenues, including curcuminoids, sunitinib, and nanoparticle-based therapies, show future promise.

Conclusions:

  • Effective management of bone metastases in breast cancer requires a multimodal approach.
  • Further research is crucial to optimize the use of existing bone-targeting drugs.
  • Emerging therapies offer potential advancements in treating bone metastatic breast cancer.
Keywords:
Metastatic breast cancer (MBC)bisphosphonatebone metastasis (BM)denosumab

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