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Oncostatin M and its role in fibrosis

Lukasz Stawski1, Maria Trojanowska1

  • 1a School of Medicine, Section of Rheumatology , Boston University , Boston , MA , USA.

Connective Tissue Research
|July 31, 2018
PubMed

Insights

Oncostatin M (OSM), a cytokine involved in inflammation, plays a key role in fibrosis. Targeting OSM may offer a new therapeutic strategy for fibrotic diseases.

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Oncostatin M (OSM) is a cytokine in the IL-6 family, produced by immune cells during infection and tissue injury.
  • OSM influences diverse cellular functions like differentiation, hematopoiesis, proliferation, and survival.
  • OSM signaling involves specific receptor complexes (LIFRβ/gp130 or OSMRβ/gp130) and downstream pathways (JAK/STAT, MAPK, PI3K).

Purpose of the Study:

  • To review the current understanding of Oncostatin M's role in fibrotic processes.
  • To explore the potential of targeting OSM for treating chronic inflammatory and fibrotic conditions.

Main Methods:

  • Literature review of studies investigating OSM's function in fibrosis.
  • Analysis of OSM's involvement in inflammation, vascular dysfunction, and fibroblast activation.

Main Results:

  • Elevated OSM levels are observed in chronic inflammatory diseases associated with fibrosis.
  • OSM contributes to key fibrotic stages, including inflammation and fibroblast activation.
  • OSM's role in vascular dysfunction within fibrotic contexts is also highlighted.

Conclusions:

  • OSM is implicated in multiple facets of the fibrotic process.
  • The association of high OSM levels with fibrotic conditions suggests its therapeutic potential.
  • Targeting OSM presents a promising avenue for developing treatments for fibrotic diseases.
Keywords:
ECMOSMfibrosisinflammationvascular injury

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