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Attainment of Recommended Lipid Targets in Patients With Familial Hypercholesterolemia: Real-World Experience With

Omar Razek1, Lubormira Cermakova2, Hamidreza Armani2

  • 1Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

The Canadian Journal of Cardiology
|July 31, 2018
PubMed

Insights

PCSK9 inhibitors significantly improved lipid control in Familial Hypercholesterolemia (FH) patients. More patients achieved LDL-C goals with PCSK9 inhibitors compared to those without, demonstrating real-world effectiveness.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Pharmacology

Background:

  • Familial Hypercholesterolemia (FH) is a common genetic disorder causing high LDL-C and increased cardiovascular risk.
  • Current lipid-lowering therapies often fail to meet treatment targets for FH patients.
  • Achieving lipid goals is crucial for preventing atherosclerotic cardiovascular disease in FH.

Purpose of the Study:

  • To evaluate the impact of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on LDL-C levels in FH patients.
  • To compare LDL-C reduction and goal attainment in FH patients with and without PCSK9 inhibitor use.
  • To assess the real-world effectiveness of PCSK9 inhibitors in managing FH.

Main Methods:

  • Retrospective analysis of FH patients from the British Columbia FH Registry (2015-2017).
  • Comparison of LDL-C levels before and after PCSK9 inhibitor availability.
  • Stratification of patients based on PCSK9 inhibitor use to analyze treatment outcomes.

Main Results:

  • Overall LDL-C decreased in the FH cohort from 2015 to 2017.
  • Patients using PCSK9 inhibitors showed a significantly greater LDL-C reduction compared to non-users.
  • 85.4% of PCSK9 inhibitor users achieved ≥ 50% LDL-C reduction or LDL-C < 2 mmol/L, versus 50.2% of non-users (P < 0.001).

Conclusions:

  • PCSK9 inhibitors have improved lipid level control in FH patients.
  • Access to PCSK9 inhibitors facilitates achievement of guideline-directed lipid goals.
  • Real-world data confirm the effectiveness of PCSK9 inhibitor therapy for FH management.
Abstract

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