Related Experiment Video
Updated: Feb 7, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
Published on: February 28, 2012
MitraClip implantation under sedation
Inês Delgado1, Ana Fonte Boa1, Ana Filipa Carvalho1
1Department of Anaesthesiology, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
The MitraClip procedure offers a less invasive option for severe mitral regurgitation in high-risk patients. This case study explores its successful application under deep sedation, improving patient quality of life.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
Background:
- Severe mitral regurgitation (MR) poses significant risks for patients unsuitable for traditional surgery.
- The MitraClip system provides a percutaneous, edge-to-edge leaflet repair alternative.
- General anesthesia is standard, but deep sedation is explored for specific patient profiles.
Observation:
- MitraClip implantation guided by 3D transesophageal echocardiography (TEE) and fluoroscopy.
- A case of MitraClip implantation performed under deep sedation using ketamine and propofol infusion is detailed.
- This approach was used in a patient with comorbidities precluding surgical repair.
Findings:
- MitraClip implantation effectively reduces mitral regurgitation, improving quality of life and functional capacity.
- The procedure avoids sternotomy and cardiopulmonary bypass, leading to shorter recovery times.
- Deep sedation with ketamine and propofol is a viable alternative to general anesthesia for MitraClip procedures.
Implications:
- Deep sedation may expand MitraClip candidacy to a broader range of high-risk patients.
- This approach can potentially reduce procedure-related risks and costs.
- Further research into sedation techniques for transcatheter valve interventions is warranted.
Related Concept Videos
Sedatives and Hypnotics: Overview
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedatives and Hypnotics Drugs: Barbiturates
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Cleavage and Blastulation
Reproductive Cloning
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...

