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Research Priorities and Resource Allocation in the Investigation of New Drugs for Cancer in Least Developed Countries

Ricardo Eccard da Silva1,2, Angélica Amorim Amato2, Débora Dornelas Belchior Costa Andrade3

  • 1Office of Clinical Trials, Brazilian Health Regulatory Agency (ANVISA), Setor de Indústria Trecho 5, Área Especial 57, 71205-050, Brasília, Brazil.

Journal of Oncology
|July 31, 2018
PubMed

Insights

Global cancer research funding often overlooks high-burden cancers in low-income nations. This study highlights the need to align oncology clinical trials with the global cancer burden, particularly for understudied diseases.

Area of Science:

  • Oncology
  • Global Health
  • Clinical Trials

Background:

  • Cancer incidence is rising in low- and middle-income countries (LMICs).
  • International health research priorities may not align with the global cancer burden.
  • Resource allocation in oncology drug development needs examination.

Purpose of the Study:

  • To analyze global trends in oncology clinical trials.
  • To discuss research priorities and resource allocation for cancers affecting LMICs.
  • To identify disparities in cancer drug development funding.

Main Methods:

  • Retrospective and analytical study design.
  • Data collected from the World Health Organization's International Clinical Trials Registry Platform (ICTRP) in 2014.

Main Results:

  • Breast and lung cancer trials were more common in lower-income countries.
  • Cervical, stomach, and liver cancer research was limited despite their high burden in LMICs.
  • Funding disparities exist for cancer types disproportionately affecting LMICs.

Conclusions:

  • Cancer research funding organizations show limited interest in prioritizing understudied, high-burden cancers in LMICs.
  • There is a misalignment between global cancer burden and research investment for specific cancer types.
  • Urgent reallocation of resources is needed to address neglected cancers in LMICs.

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