Reference Data on Neonatal Serum N-Acetyl-β-hexosaminidase Activity
Sylwia Chojnowska1, Monika Kamianowska2, Piotr Baran3
1Faculty of Health Sciences, Lomza State University of Applied Sciences, Łomża, Poland.
Disease Markers
|July 31, 2018
Summary
Neonatal serum N-acetyl-β-hexosaminidase (HEX) activity reference values were established. HEX activity correlates with birth weight, sex, and inflammation markers, aiding neonatal diagnostics.
Area of Science:
- Biochemistry
- Neonatal Medicine
- Clinical Diagnostics
Background:
- N-acetyl-β-hexosaminidase (HEX) is an enzyme crucial for cellular function.
- Understanding neonatal HEX activity is important for diagnosing various conditions.
Purpose of the Study:
- Establish reference ranges for neonatal serum HEX activity.
- Determine the diagnostic significance of HEX activity in newborns.
Main Methods:
- Colorimetric determination of HEX activity in 111 neonate serum samples (aged 1-30 days).
- Analysis of correlations between HEX activity and clinical factors.
Main Results:
- Mean neonatal serum HEX activity was 360.5 ± 114.0 nKat/L.
- Significant positive correlations found with gestational age, birth weight, weight at collection, sex, and CRP levels.
Conclusions:
- Provided reference values for neonatal serum HEX activity can aid in diagnostics.
- HEX activity may help detect inflammation and assess risks for lysosomal storage diseases like Tay-Sachs and Sandhoff.
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