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Updated: Feb 7, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Management of T-cell large granular lymphocyte leukemia and concurrent retroperitoneal liposarcoma
Nolan R Bruce1, Zachary W Tilley2, Jacob T Carlson1
1Department of General Surgery, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR, USA.
Abstract:
T-cell large granular leukemia (T-LGL) is a rare lymphoproliferative disorder characterized by the clonal expansion of cytotoxic T lymphocytes. We present a unique case of T-LGL and concurrent retroperitoneal sarcoma occurring in a patient with long-standing rheumatoid arthritis. Pathology revealed a high-grade dedifferentiated liposarcoma. The diagnosis of T-LGL with a synchronous retroperitoneal sarcoma is a case that highlights the surgical management of these two rare conditions.
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