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Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia
Tomoaki Tanaka1,1, Akinori Minami1,1, Kouichiro Tashiro2,3,2,3
1Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan.
Aim:
To investigate whether urine levels of miRNAs that regulate the function of endothelial cells are associated with effectiveness in benign prostatic hyperplasia (BPH) patients treated with a phosphodiesterase type 5 inhibitor, tadalafil.
Patients & Methods:
We measured urine levels of three miRNAs (miR-21-5p, miR-126-5p & miR-155-5p) in 55 BPH patients before and after tadalafil administration to understand its effectiveness.
Results:
Baseline urine miR-21-5p level was an independent predictor of response to tadalafil in multivariate regression analysis (odds ratio: 0.28; 95% CI: 0.10-0.77; p = 0.014). Receiver operator curve analysis revealed that baseline urine miR-21-5p could serve as a predictor of response (area under curve: 0.85; 95% CI: 0.75-0.95; p < 0.001).
Conclusion:
Urine miR-21-5p could serve as a biomarker in predicting response of tadalafil for BPH.
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