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Updated: Feb 7, 2026
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Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol
Published on: September 7, 2018
12.1K
Imaging sequence for joint myocardial T1 mapping and fat/water separation
Maryam Nezafat1,2, Shiro Nakamori2, Tamer A Basha3
1Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.
Magnetic Resonance in Medicine
|July 31, 2018
Summary
A new cardiac MRI sequence simultaneously measures epicardial fat volume and myocardial T1 relaxation time, improving efficiency in clinical protocols.
Area of Science:
- Cardiovascular Magnetic Resonance Imaging
- Quantitative Imaging Techniques
Background:
- Epicardial adipose tissue (EAT) is metabolically active and linked to cardiovascular disease.
- Myocardial T1 relaxation time is a sensitive biomarker for diffuse myocardial disease.
Purpose of the Study:
- To develop and validate a novel simultaneous T1 mapping and fat/water separation imaging sequence.
- To enable concurrent quantification of epicardial fat volume and myocardial T1 values.
Main Methods:
- A joint T1-fat/water separation sequence using dual-echo Dixon reconstruction was developed.
- Phantom studies assessed accuracy and fat/water separation capabilities.
- In vivo evaluation in 17 subjects compared the novel sequence with standard methods.
Main Results:
- The sequence accurately separated oil and water in phantoms.
- Intravoxel fat effects on T1 maps were significantly reduced.
- In vivo, myocardial T1 values and epicardial fat volumes showed no significant differences compared to separate measurements.
Conclusions:
- The proposed sequence enables simultaneous, accurate quantification of myocardial T1 and epicardial fat volume.
- This integrated approach streamlines cardiac MRI protocols, reducing scan time and complexity.
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