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Maternal recurrent pregnancy loss is associated with an increased risk for long-term neurological morbidity in

Dorit Paz Levy1, Tamar Wainstock2, Eyal Sheiner1

  • 1Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Developmental Medicine and Child Neurology
|July 31, 2018
PubMed

Insights

Maternal history of recurrent pregnancy loss (RPL) is linked to increased neurological issues in children. This includes higher rates of epilepsy and developmental disorders, indicating a significant long-term impact on offspring neurological health.

Area of Science:

  • Obstetrics and Gynecology
  • Pediatric Neurology
  • Reproductive Medicine

Background:

  • Recurrent pregnancy loss (RPL) affects a significant number of pregnancies.
  • The long-term neurological health implications for offspring of mothers with RPL are not fully understood.

Purpose of the Study:

  • To investigate the association between a maternal history of recurrent pregnancy loss (RPL) and the long-term neurological health of offspring.

Main Methods:

  • A population-based cohort analysis included singletons born between 1991-2014.
  • Neurological morbidity (cognitive, motor, psychiatric disorders) up to age 18 was compared between children of mothers with and without RPL history.
  • Survival curves and a Weibull multivariable survival model were used to analyze cumulative incidence and control for confounders.

Main Results:

  • Children born to mothers with RPL showed significantly higher incidences of epilepsy and developmental disorders.
  • Maternal RPL was independently associated with childhood epilepsy (aHR 1.23) and developmental disorders (aHR 2.41).

Conclusions:

  • Maternal history of recurrent pregnancy loss is independently associated with increased long-term neurological morbidity in offspring.
  • Hospitalizations for epilepsy and developmental disorders are more frequent in children whose mothers experienced RPL.
Abstract

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