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GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI.

Xiang Xu1,2, Jiadi Xu1,2, Kannie W Y Chan1,2,3

  • 1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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The on-resonance variable delay multi-pulse (onVDMP) MRI technique shows 1.8 times higher sensitivity for detecting D-glucose compared to conventional continuous wave (CW) CEST MRI.

Keywords:
Chemical exchangegliomaglucoCESTon-resonance variable delay multiple pulse (onVDMP)

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Area of Science:

  • Biomedical Imaging
  • Magnetic Resonance Imaging
  • Biochemistry

Background:

  • Chemical Exchange Saturation Transfer (CEST) MRI is a functional MRI technique.
  • D-glucose is a key metabolite with rapidly exchanging hydroxyl protons.
  • Detecting changes in D-glucose concentration is important for various physiological and pathological processes.

Purpose of the Study:

  • To evaluate the detection sensitivity of the on-resonance variable delay multi-pulse (onVDMP) CEST technique.
  • To assess the onVDMP technique for detecting D-glucose in vivo.
  • To compare the performance of onVDMP CEST with conventional continuous wave (CW) CEST MRI.

Main Methods:

  • The onVDMP CEST MRI technique was applied to mice with 9L glioma xenografts.
  • D-glucose was infused intravenously to induce measurable signal changes.
  • Signal changes detected by onVDMP MRI were compared with those from CW-CEST MRI.

Main Results:

  • Both onVDMP and CW-CEST MRI highlighted tumors and blood vessels during D-glucose infusion.
  • The mean signal changes detected by onVDMP were 1.8 times higher than those by CW-CEST.
  • Higher sensitivity of onVDMP was attributed to efficient labeling of fast-exchanging protons over a broader frequency range.

Conclusions:

  • The onVDMP CEST technique demonstrates superior sensitivity for detecting exogenous agents with fast-exchanging protons.
  • onVDMP MRI is a more effective method than CW-CEST MRI for detecting D-glucose.
  • This technique holds promise for improved metabolic imaging applications.