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Updated: Feb 7, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
[Bottlenecks and modification strategies of 1,3-propanediol biosynthesis from glycerol]
Miaomiao Yang1, Junhua Yun1, Huanhuan Zhang1
1School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China.
Abstract:
Crude glycerol is the main by-product of biodiesel production. A few microorganisms can transfer crude glycerol to 1,3-propanediol (1,3-PD) that is an important chemical material. There exist many limitations such as substrate inhibition, product inhibition when wild strains are used in 1,3-PD biosynthesis. In this review, based on the microbial transformation of 1,3-propanediol from glycerol and its limitations, some strategies using genetic engineering such as knockout or gene overexpression were summarized. The latest research progresses in biosynthesis of 1,3-propanediol from glycerol by genetically engineered strains are discussed.
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