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Published on: March 11, 2022
[Evaluation of renal function in the course of hypertension in the elderly]
Monika Rynkowska-Kidawa1, Michał Kidawa2, Joanna Kapusta3
1Medical University of Lodz, MCM Jonscher, Łódź, Poland: Department of Internal Diseases and Geriatrics.
Insights
This study found that estimated glomerular filtration rate (GFR) in elderly hypertensive patients depends on hypertension duration. Renal artery resistance index showed a relationship with age but not hypertension duration.
Area of Science:
- Gerontology
- Nephrology
- Cardiology
Background:
- Hypertension is a prevalent chronic condition in Poland, particularly affecting individuals over 65.
- Accurate diagnosis in older adults involves assessing blood pressure, differentiating aging-related changes, and evaluating organ complications for prognostic insights.
Purpose of the Study:
- To evaluate renal function in elderly patients with hypertension.
- To assess the impact of hypertension duration and age on renal function parameters.
Main Methods:
- The study included 80 elderly patients (75-93 years) diagnosed with arterial hypertension.
- Patients were stratified by age (over 85 vs. 75-85) and hypertension duration (up to 10 years vs. over 10 years).
- Glomerular filtration rate (GFR) was estimated using the MDRD formula, and renal resistance index was measured via spectral Doppler.
Main Results:
- GFR values differed based on age groups.
- A relationship was observed between the renal artery resistance index and patient age.
- No significant correlation was found between the renal artery resistance index and the duration of hypertension.
Conclusions:
- Estimated GFR is influenced by the duration of hypertension in the elderly.
- Renal artery resistance index is associated with age in hypertensive elderly individuals.
- The duration of hypertension does not significantly impact the renal artery resistance index.
Abstract:
Hypertension is one of the most common chronic diseases in Poland. It occurs in all age groups, but most often affects people over 65 years of age. The correct diagnosis of hypertension in older people includes documenting elevated blood pressure values, differentiating disease changes from physiologically related changes to aging, as well as assessing organ related complications. Detection of organ complications is also an important parameter of prognosis assessment.
Aim:
The aim of the study was evaluation of renal function in the course of hypertension in the elderly.
Materials And Methods:
The study involved 63 women and 17 men, aged from 75 to 93 years, who were diagnosed with arterial hypertension in accordance with the guidelines of the Polish Society of Hypertension. Patients were divided into two groups. The first pair consisted of a group of 1 hypertensive patients (HA) lasting up to 10 years of age over 85 years and a group of 2 patients with HA lasting up to 10 years at the age of 75-85 years. The second pair is group I - patients with HA over 10 years of age over 85 years and group II - patients with HA lasting over 10 years at the age of 75-85. The assessment of glomerular filtration was made using the estimated glomerular filtration rate (GFR), which was calculated according to the mathematical formula of MDRD, while the renal resistance index was assessed using spectral Doppler after visualization of the flow in the renal arteries.
Results:
The value of glomerular filtration in the examined groups divided by age was 55.1±15 (group 1) and 66.9±16 (group 2). The values of the kidney artery resistance index (depending on age) were in 1 group: 0.61±0.04 vs 0.60±0.05 and in the second group: 0.59±0.06 vs 0.58±0.05. The values of the renal artery resistance index (depending on the duration of HA) were 0.62±0.04 vs 0.61±0.03 (group I) and 0.61±0.04 vs 0.60±0.04 ( group II).
Conclusions:
GFR depends on the duration of hypertension. A relationship was found between the value of the kidney artery resistance index and age. There was no significant relationship between the value of the kidney artery resistance index and duration of hypertension.
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