Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility

Our pooled analysis aimed to assess the impact of vitamin D receptor (VDR) gene polymorphism on chronic renal failure (CRF) susceptibility. Relevant studies were searched from multiple databases, then pooled-analyses were performed using Stata software. Eighteen studies involving 2512 CRF patients and 3630 healthy controls were included. Pooled analysis showed that VDR ApaI and TaqI gene polymorphism were not associated with CRF susceptibility either in Asian or in Caucasians populations, and VDR BsmI and FokI gene polymorphism were not associated with CRF susceptibility in overall populations. The subgroup analysis showed that VDR BsmI gene polymorphism was associated with CRF susceptibility in Chinese under the Allele model (OR = 0.76, 95% CI: 0.59-0.97, P = 0.029). In Spanish individuals, VDR BsmI gene polymorphism was associated with CRF: Recessive model (BB vs. Bb + bb): OR = 1.60, 95% CI: 1.09-2.35, P = 0.016; Additive model (BB + bb vs. Bb): OR = 1.60, 95% CI: 1.21-2.12, P = 0.001). In addition, in the Asian subgroup, VDR FokI gene polymorphism was associated with CRF risk: Allele model (F vs. f): OR = 0.31, 95% CI: 0.16-0.59, P = 0.000; Dominant model (FF + Ff vs. ff): OR = 0.12, 95% CI: 0.03-0.59, P = 0.009 and Recessive model (FF vs. Ff + ff): OR = 0.32, 95% CI: 0.13-0.75, P = 0.009. This pooled analysis showed that VDR BsmI gene polymorphism was associated with CRF risk in the Chinese and Spanish individuals, and, VDR FokI gene polymorphism was associated with CRF risk in Asian subjects. But VDR ApaI and TaqI gene polymorphism were not associated with CRF risk either in Asian or in Caucasian individuals.