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Related Experiment Videos

Opioid peptides decrease noradrenaline release and blood pressure in the rabbit at peripheral receptors.

B Szabo, L Hedler, H Ensinger

    Naunyn-Schmiedeberg'S Archives of Pharmacology
    |January 1, 1986
    PubMed
    Summary
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    Opioid peptides like dynorphin and D-Ala2,D-Leu5-enkephalin (DADLE), along with bremazocine, reduce noradrenaline release and blood pressure in rabbits. Naloxone reversed these effects, indicating opioid receptor involvement.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Cardiovascular Physiology

    Background:

    • Opioid peptides modulate sympathetic nervous system activity.
    • Understanding their cardiovascular effects is crucial for therapeutic development.

    Purpose of the Study:

    • To investigate the effects of dynorphin-(1-13), Leu5-enkephalin, D-Ala2,D-Leu5-enkephalin (DADLE), and bremazocine on sympathetic outflow and blood pressure.
    • To explore the mechanisms underlying these effects, including opioid receptor involvement.

    Main Methods:

    • Experiments conducted in pithed rabbits.
    • Electrical stimulation of sympathetic outflow to assess noradrenaline release and mean arterial pressure (MAP).
    • Administration of opioid peptides and bremazocine, followed by naloxone challenge.

    Related Experiment Videos

  • Infusion of exogenous noradrenaline to evaluate pressor responses.

    • Main Results:

    • Dynorphin, DADLE, Leu5-enkephalin, and bremazocine significantly reduced electrically-evoked increases in plasma noradrenaline and MAP.
    • These effects were antagonized by naloxone.
    • Opioid peptides did not significantly alter the pressor response to exogenous noradrenaline.
    • Dynorphin's effect was not diminished by concurrent DADLE infusion, while DADLE's effect was abolished.

    Conclusions:

    • Opioid peptides and bremazocine decrease action potential-evoked noradrenaline release and consequently lower blood pressure.
    • The findings suggest a role for opioid receptors in regulating sympathetic noradrenaline release.