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Updated: Feb 7, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
Published on: June 19, 2019
[Sleep and wakefulness disorders in neurodegenerative diseases]
O V Yakovleva1, M G Poluektov2, O S Levin1
1Russian Medical Academy of Continuous Professional Education, Moscow, Russia.
Abstract:
The article reviews the phenomenology of sleep and wakefulness disorders in Parkinson's disease and Alzheimer's disease. Degeneration of sleep and wakefulness centers, secondary effect of other symptoms of diseases and side-effects of drug therapy lead to a widespread prevalence of sleep and wakefulness disturbances in these patients. Along with the review of actual literature concerning mechanisms of development and clinical features of these disorders, the authors discuss principal methods for their treatment.
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