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Updated: Feb 7, 2026

Demonstration of the Rat Ischemic Skin Wound Model
Published on: April 1, 2015
Treatment of Nonreconstructable Critical Limb Ischemia With Ischemic Wounds Utilizing a Noninvasive Intermittent
Charles A Andersen1, Leo J Daab2, Thuy-Duong Le3
1Madigan Army Medical Center, Tacoma, WA; Midwest Podiatry Services, Wichita, KS; BSN Medical, Tacoma, WA; and Scriptum Medica, University Place, WA.
Introduction:
Critical limb ischemia (CLI) is a leading cause of lower extremity amputation. When CLI is identified, revascularization should be performed if possible. When options for revascularization do not exist, use of a noninvasive intermittent pneumatic compression device (NPCD) can be considered.
Objective:
Presented here are 2 cases of patients with nonreconstructable CLI at risk for limb loss who were serially assessed with indocyanine green fluorescence angiography (ICGFA) to determine the effects of NPCD use on local tissue perfusion.
Materials And Methods:
Both patients were treated with the NPCD for 1 hour, 3 times per day, for 4 weeks. Serial ICGFA utilizing a ICGFA device was performed at various time points to monitor the effects of NPCD use on tissue perfusion.
Results:
The treatment of both patients with serial ICGFA provided limited objective evidence of increased local tissue perfusion which expedited wound resolution.
Conclusions:
Larger randomized control trials of this modality of perfusion assessment and NPCD use are recommended.
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