Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Circulation01:21

Coronary Circulation

7.3K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.3K
Fetal Circulation01:14

Fetal Circulation

3.0K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
3.0K
Density00:56

Density

19.9K
Density is an important characteristic of substances, crucial in determining whether an object sinks or floats in a fluid. Its SI unit is kg/m3, and its cgs unit is g/cm3. The density of an object helps in identifying its composition, and also reveals information about the phase of the matter and its substructure. The densities of liquids and solids are roughly comparable, consistent with the fact that their atoms are in close contact. However, gases have much lower densities than liquids and...
19.9K
Overview of Pulmonary Circulation01:19

Overview of Pulmonary Circulation

3.2K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
3.2K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

111.0K
Overview
111.0K
Current Density01:21

Current Density

5.2K
The total amount of current flowing through one unit value of a cross-sectional area is referred to as current density. If the current flow is uniform, the amount of current flowing through a conductor is the same at all points along the conductor, even if the conductor area varies. The current density consists of the local magnitude and direction of the charge flow, which varies from point to point. Current density is measured in amperes per meter square, and direction is defined as the net...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Systematic Review of Factors Affecting Utilization of Decision Support Systems: The Interplay Between Technology, Users, and the Healthcare Environment.

Health science reports·2026
Same author

Performance of Large Language Models in Answering Healthcare Delivery Questions: A Quantitative Cross-Sectional Study.

Health science reports·2026
Same author

Barriers to the Implementation of Iran's Clean Air Act: A Policy-Oriented Scoping Review.

Environmental health insights·2026
Same author

Development of a pH-responsive starch-based nanocarrier polyacrylic acid containing SiO<sub>2</sub> for controlled quercetin release in cancer therapy.

Scientific reports·2026
Same author

VAV2-associated ncRNA network in the focal adhesion pathway is dysregulated in laryngeal squamous cell carcinoma.

Discover oncology·2026
Same author

Effect of virtual reality (VR) technology on anxiety control and acrophobia reduction: A randomized controlled trial in Iran.

Global mental health (Cambridge, England)·2026
Same journal

Metabolic burden is independently and linearly associated with lower testosterone levels: evidence from NHANES.

Hormone molecular biology and clinical investigation·2026
Same journal

Effect of Vitamin B12 supplementation on glycemic control, albuminuria and peripheral neuropathy in diabetes mellitus patients - a cross sectional study.

Hormone molecular biology and clinical investigation·2026
Same journal

Mechanisms of Notch signaling in cancer drug resistance.

Hormone molecular biology and clinical investigation·2026
Same journal

Indications that the direct effects of supplemented vitamin D3 on the adrenal cortex are of secondary importance for glucocorticoid output.

Hormone molecular biology and clinical investigation·2026
Same journal

Metabolic hormones, nitric oxide signaling components, and inflammation markers crosstalk in coronary artery disease.

Hormone molecular biology and clinical investigation·2026
Same journal

Dienogest-associated capillaroscopic abnormalities: a case report and narrative review of progestin microvascular effects.

Hormone molecular biology and clinical investigation·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Fast and Simplified Method for High Through-put Isolation of miRNA from Highly Purified High Density Lipoprotein
09:48

Fast and Simplified Method for High Through-put Isolation of miRNA from Highly Purified High Density Lipoprotein

Published on: July 27, 2016

12.4K

Circulating low density lipoprotein (LDL).

Mohsen Khosravi1, Reza Hosseini-Fard2, Mohammad Najafi3

  • 1Biochemistry Department, Iran University of Medical Sciences, Tehran, Iran.

Hormone Molecular Biology and Clinical Investigation
|July 31, 2018
PubMed
Summary
This summary is machine-generated.

Low-density lipoprotein (LDL) particles contribute to atherosclerosis by accumulating in macrophages, forming foam cells. This review details the cellular mechanisms of cholesterol homeostasis and LDL uptake in atherosclerosis development.

Keywords:
LDLatherosclerosischolesterollipid dropletlipoproteinmacrophage

More Related Videos

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K
Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein
07:26

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein

Published on: August 12, 2025

735

Related Experiment Videos

Last Updated: Feb 7, 2026

Fast and Simplified Method for High Through-put Isolation of miRNA from Highly Purified High Density Lipoprotein
09:48

Fast and Simplified Method for High Through-put Isolation of miRNA from Highly Purified High Density Lipoprotein

Published on: July 27, 2016

12.4K
Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K
Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein
07:26

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein

Published on: August 12, 2025

735

Area of Science:

  • Cardiovascular Biology
  • Cellular Metabolism
  • Atherosclerosis Research

Background:

  • Low-density lipoprotein (LDL) particles are key atherogenic agents in coronary artery disease.
  • Modified LDL particles promote inflammatory events within blood vessel walls.
  • Plasma PCSK-9 levels correlate with circulating LDL concentrations.

Purpose of the Study:

  • To review the cellular and molecular mechanisms of cholesterol homeostasis.
  • To elucidate the pathways of LDL uptake and processing by macrophages.
  • To understand the role of cellular lipid accumulation in foam cell formation and atherosclerosis.

Main Methods:

  • Literature review focusing on cellular and molecular biology of cholesterol transport.
  • Analysis of LDL internalization via lysosomal receptor-mediated pathways.
  • Examination of the role of scavenger receptors and intracellular trafficking proteins (Rab, Lamp families) in cholesterol homeostasis.

Main Results:

  • LDL uptake by macrophages involves scavenger receptors and vesicular trafficking.
  • Proteins like Rab and Lamp facilitate cholesterol transport from lysosomes to the cytosol.
  • Intracellular lipid aggregation leads to foam cell formation, contributing to atherosclerotic plaques.

Conclusions:

  • Cellular cholesterol homeostasis is critical in the pathogenesis of atherosclerosis.
  • Dysregulation of LDL uptake and trafficking contributes to foam cell formation.
  • Understanding these pathways offers potential targets for managing cardiovascular disease.