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Updated: Feb 7, 2026

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
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Screening for Autism Spectrum Disorder: Profiles of Children Who Are Missed

Chloe Beacham1, Morganne Reid1, Jessica Bradshaw1,2

  • 1Marcus Autism Center, Children's Healthcare of Atlanta, Atlanta, GA.

Journal of Developmental and Behavioral Pediatrics : JDBP
|July 31, 2018
PubMed

Insights

A combined screening approach using the M-CHAT-R and ASQ-3 identified 93% of children with autism spectrum disorder (ASD). This method improves early detection of ASD in young children.

Area of Science:

  • Developmental Pediatrics
  • Child Psychology
  • Clinical Diagnostics

Background:

  • Parent-report screeners like the M-CHAT-R and ASQ-3 are crucial for early identification of autism spectrum disorder (ASD).
  • However, some children with ASD may be missed by these individual screeners, necessitating further investigation into their characteristics and improved screening strategies.

Purpose of the Study:

  • To characterize children with ASD who were not identified by standard parent-report screeners.
  • To evaluate the effectiveness of a combined screening approach using the M-CHAT-R and ASQ-3 for ASD detection.

Main Methods:

  • 154 children aged 16-42 months underwent ASD evaluations.
  • Caregivers completed the M-CHAT-R, ASQ-3, and demographic questionnaires.
  • Diagnostic assessments included the Mullen Scales of Early Learning (Mullen) and the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2).

Main Results:

  • 81% of children were diagnosed with ASD (n=124).
  • The M-CHAT-R identified 85% of ASD cases; missed cases showed higher Mullen and lower ADOS-2 scores.
  • A combined M-CHAT-R and ASQ-3 communication domain screen identified 93% of children with ASD.

Conclusions:

  • Children with ASD missed by individual screeners still exhibited developmental delays.
  • A combined screening approach integrating the M-CHAT-R and ASQ-3 significantly enhances ASD identification rates in a clinical referral setting.
Abstract

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