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Polymer Probe Diffusion in Globular Protein Gels and Aggregate Suspensions.

Walailuk Inthavong1, Taco Nicolai1, Christophe Chassenieux1

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Area of Science:

  • Biomaterials science
  • Polymer physics
  • Protein aggregation

Background:

  • Macromolecule transport is crucial for protein-based biomaterials in pharmaceuticals, food, and cosmetics.
  • Previous research focused on polymer mobility in protein gels, but not in dense aggregate suspensions.

Purpose of the Study:

  • Investigate the self-diffusion of probe dextran chains in protein aggregate suspensions and gels.
  • Determine how aggregate size, morphology, and concentration affect polymer mobility.
  • Characterize diffusion behavior in different protein aggregate structures.

Main Methods:

  • Utilized fluorescence recovery after photobleaching (FRAP) to measure dextran chain diffusion.
  • Studied suspensions of protein aggregates with varying size and morphology.
  • Examined protein gels across a wide range of concentrations.

Main Results:

  • Observed Brownian diffusion in aggregate suspensions and weak gels.
  • Polymer diffusion in dense aggregate suspensions is influenced by aggregate size and morphology, independent of viscosity or correlation length.
  • Diffusion in protein gels is anomalous, exhibiting logarithmic time dependence.

Conclusions:

  • Aggregate characteristics significantly impact polymer diffusion in suspensions.
  • Anomalous, logarithmic diffusion in protein gels suggests an exponential distribution of diffusion coefficients.
  • Findings provide insights into macromolecule transport in protein-based biomaterials.