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Pharmacological modulation of colorectal distension evoked potentials in conscious rats

Thomas Dahl Nissen1, Christina Brock2, Jens Lykkesfeldt3

  • 1Laboratory Animal Sciences, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden; Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Neuropharmacology
|July 31, 2018
PubMed
Abstract

Keywords:
(2-methyl-6-(phenylethynyl)-pyridine) hydrochlorideAnalgesicsCB1CEPCRDCannabinoid receptor 1Cerebral evoked potentialColorectal distensionGABABIBSICCIntra-class correlation coefficientsIrritable bowel syndromeMPEPRatsVMRVisceral painVisceromotor responseWIN55WIN55,212-2 [[(R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-napthalenyl-methanone], mesylate form]γ-aminobutyric acid B receptor

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