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Related Experiment Video

Updated: Feb 7, 2026

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

Modulating SIRT1 activity variously affects thymic lymphoma development in mice.

Katherine V Clark-Knowles¹, Danielle Dewar-Darch¹, Karen E Jardine¹

¹Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Canada.

Experimental Cell Research

|July 31, 2018

Summary

Sirtuin 1 (SIRT1) plays a complex role in cancer. This study shows SIRT1 can both suppress and promote tumor development depending on the cancer type, suggesting a role in tumor surveillance.

Keywords:

Cancer Lymphoma Oncogene SIRT1 Thymus

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Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

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Published on: April 3, 2011

Preparation and Applications of Organotypic Thymic Slice Cultures

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Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

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Published on: October 27, 2020

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Sirtuin 1 (SIRT1) is a protein deacetylase implicated in various biological processes.
The role of SIRT1 in carcinogenesis is complex and often contradictory in existing literature.
Understanding SIRT1's specific functions in cancer initiation and progression is crucial.

Purpose of the Study:

To investigate the precise role of SIRT1 in the development of thymic T cell lymphomas.
To determine if SIRT1 acts as an oncogene or tumor suppressor in different cancer models.
To elucidate the influence of SIRT1 modulation on carcinogenesis.

Main Methods:

Utilized mouse models with absent or modulated SIRT1 activity.
Induced thymic lymphoma using N-nitroso-N-methylurea (NMU) or a nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) transgene.
Assessed the impact of decreased SIRT1 activity on lymphoma and lung adenoma formation.

Main Results:

Reduced SIRT1 activity inhibited thymic lymphoma development in NMU-treated mice.
Decreased SIRT1 activity promoted lung adenoma formation in NMU-treated mice.
Modest promotion of thymic lymphoma was observed with decreased SIRT1 activity in NPM-ALK transgenic mice.

Conclusions:

SIRT1 is not a simple oncogene or tumor suppressor.
SIRT1's influence on carcinogenesis varies depending on the specific cancer context.
Findings suggest SIRT1 may play a role in tumor surveillance, impacting cancer initiation and progression differently across models.