Related Experiment Video
Updated: Feb 7, 2026
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Establishing nationally representative central line-associated bloodstream infection surveillance data for paediatric
S Kouni1, M Tsolia2, E Roilides3
1Center for Clinical Epidemiology and Outcomes Research (CLEO), Non-Profit Civil Partnership, Athens, Greece.
Insights
Healthcare-associated infections, specifically central line-associated bloodstream infections (CLABSIs) in children, were studied. National benchmark data for CLABSI rates were established for neonatal and pediatric intensive care units.
Area of Science:
- Pediatric Infectious Diseases
- Healthcare Epidemiology
- Clinical Microbiology
Background:
- Healthcare-associated infections (HCAIs) significantly increase patient morbidity, mortality, and healthcare costs.
- Central line-associated bloodstream infections (CLABSIs) represent the most prevalent HCAIs in pediatric and neonatal populations.
Purpose of the Study:
- To establish national benchmark data for central line-associated bloodstream infection (CLABSI) rates.
- To provide baseline data for neonatal intensive care units (NICUs), pediatric intensive care units (PICUs), and pediatric oncology units (ONCs).
Main Methods:
- Active surveillance for CLABSI was conducted across 14 NICUs, 4 PICUs, and 6 ONCs from June 2016 to February 2017.
- Surveillance definitions adhered to the Centers for Disease Control and Prevention's 2014 National Healthcare Safety Network criteria.
- Data collected included central line days, patient days, and pathogen susceptibility testing.
Main Results:
- A total of 111 CLABSI episodes were recorded, with an overall mean CLABSI rate of 4.41 per 1000 central line days.
- CLABSI rates varied by unit: 6.02 in NICUs, 6.09 in PICUs, and 2.78 per 1000 central line days in ONCs.
- Enterobacteriaceae (36%) were the most common pathogens; significant antimicrobial resistance was noted, with 37% of Gram-negative pathogens resistant to third-generation cephalosporins and carbapenems.
Conclusions:
- Nationally representative CLABSI rates for pediatric patients were determined.
- These benchmark data are crucial for evaluating and designing infection control strategies.
- The findings support the development of antimicrobial stewardship interventions in pediatric healthcare settings.
Background:
Healthcare-associated infections (HCAIs) are associated with increased morbidity and mortality and with excess costs. Central line-associated bloodstream infections (CLABSIs) are the most common HCAIs in neonates and children.
Aim:
To establish national benchmark data for rates of CLABSI in neonatal and paediatric intensive care units (NICUs and PICUs) and paediatric oncology units (ONCs).
Methods:
Active surveillance for CLABSI was conducted from June 2016 to February 2017. A collaborative of 14 NICUs, four PICUs, and six ONCs participated in the programme. Surveillance definitions of central line (CL), central line utilization (CLU) ratio, CLABSI event, and CLABSI rate were based on the Centers for Disease Control and Prevention's 2014 National Healthcare Safety Network criteria. Medical records were assessed daily for calculating CL-days, patient-days, and susceptibility of isolated organisms.
Findings:
A total of 111 CLABSI episodes were recorded. The overall mean CLABSI rate was 4.41 infections per 1000 CL-days, and the CLU ratio was 0.31. CLABSI rates were 6.02 in NICUs, 6.09 in PICUs, and 2.78 per 1000 CL-days in ONCs. A total of 123 pathogens were isolated. The most common pathogens were Enterobacteriaceae (36%), followed by Gram-positive cocci (29%), non-fermenting Gram-negative bacteria (16%), and fungi (16%). Overall, 37% of Gram-negative pathogens were resistant to third-generation cephalosporins and 37% to carbapenems.
Conclusion:
Nationally representative CLABSI rates were determined for paediatric patients. These data could be used to benchmark and serve as baseline data for the design and evaluation of infection control and antimicrobial stewardship interventions.
More Related Videos
06:52The Establishment and Utilization of Patient Derived Xenograft Models of Central Nervous System Metastasis
Published on: May 7, 2021
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
Related Concept Videos
02:13The Representativeness Heuristic
01:26National Nursing Organizations I
02:16Measures of Central Tendency
01:30National Nursing Organizations II
The AACN emphasizes a healthy work environment through six standards to achieve an optimal patient outcome. The standards are appropriate staffing, meaningful recognition, collaboration, authentic leadership, effective communication, and decision-making. In addition, AACN provides certification programs, webinars, journals, and...
01:25The Central Dogma
01:26Principles of Disease Surveillance