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[Induction of anti-glomerular basement membrane antibodies in BN rats: genetic control]
Mercuric chloride induces anti-glomerular basement membrane antibodies in Brown Norway rats (Ag B3) and not in Lewis rats (Ag B1). Studies on (Lewis X BN) F1 and F2 and with back-crosses (Lewis X BN) F1 X Lewis demonstrate a genetic control for this immune response. This genetic control probably depends on two non-linked, autosomal and dominant genes. One of these genes is linked to the major histocompatibility locus.
Mercuric chloride induces anti-glomerular basement membrane antibodies in Brown Norway rats (Ag B3) and not in Lewis rats (Ag B1). Studies on (Lewis X BN) F1 and F2 and with back-crosses (Lewis X BN) F1 X Lewis demonstrate a genetic control for this immune response. This genetic control probably depends on two non-linked, autosomal and dominant genes. One of these genes is linked to the major histocompatibility locus.