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Updated: Feb 7, 2026
07:10
Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
Published on: June 18, 2020
22.8K
Mortality Among Patients With Chronic Hepatitis B Infection: The Chronic Hepatitis Cohort Study (CHeCS).
Danae Bixler1, Yuna Zhong1, Kathleen N Ly1
1Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia.
Summary
Chronic hepatitis B (CHB) patients die 14 years younger than the general population, facing higher mortality rates from all causes and liver disease. Official death certificates significantly underestimate CHB
Area of Science:
- Hepatology
- Public Health
- Epidemiology
Background:
- Hepatitis B virus (HBV) infection can lead to chronic hepatitis B (CHB).
- Annual mortality data from death certificates may not fully capture the true burden of CHB-related deaths in the United States.
Purpose of the Study:
- To compare mortality rates and age at death among CHB patients versus the general US population.
- To assess the accuracy of death certificates in reporting CHB as a cause of death.
Main Methods:
- Analysis of data from the Chronic Hepatitis Cohort Study (CHeCS) between 2006 and 2013.
- Comparison of death rates and causes between CHB decedents and the US Multiple Cause of Death (MCOD) file.
Main Results:
- CHB patients died at a mean age of 59.8 years, 14 years younger than the general population.
- CHB patients exhibited significantly higher overall (RR=1.85) and liver-related mortality (RR=15.91).
- Hepatitis B was underreported on death certificates for CHB decedents (19%) and those dying of liver disease (40%).
Conclusions:
- CHB is associated with premature mortality and increased risk of death from all causes and liver disease.
- Current death certificate data likely underestimate the mortality impact of CHB.
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