Related Experiment Video

Updated: Feb 7, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

9.7K

Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver

Loris Riccardo Lopetuso1, Giammarco Mocci2, Manuela Marzo3

  • 1Internal Medicine and Gastroenterology Department, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, 00168 Roma, Italy. lopetusoloris@libero.it.

International Journal of Molecular Sciences
|August 1, 2018
PubMed

Insights

Anti-tumor necrosis factor (TNF)-α agents are effective for inflammatory diseases but can affect liver function. This review examines their hepatic safety and potential therapeutic benefits in various liver conditions.

Area of Science:

  • Hepatology
  • Immunology
  • Pharmacology

Background:

  • Anti-tumor necrosis factor (TNF)-α agents are widely used for chronic inflammatory diseases.
  • Concerns exist regarding their impact on liver function, yet evidence suggests therapeutic potential in certain liver diseases.

Purpose of the Study:

  • To review the hepatic safety of anti-TNF-α agents in patients with and without pre-existing liver conditions.
  • To discuss the potential benefits of anti-TNF-α agents in treating specific liver diseases.

Main Methods:

  • Literature review of studies on anti-TNF-α agents and liver diseases.
  • Analysis of safety data and efficacy evidence from clinical trials and observational studies.

Main Results:

  • Anti-TNF-α agents are generally safe in patients with chronic hepatitis B/C and liver transplant recipients, requiring monitoring.
  • Anti-TNF-α-induced liver injury can occur but is often reversible upon drug withdrawal.
  • Limited data exist on efficacy in autoimmune hepatitis and primary biliary cholangitis, with ongoing research in alcoholic and non-alcoholic fatty liver disease.

Conclusions:

  • Anti-TNF-α agents present a complex profile regarding liver health, with both risks and potential benefits.
  • Careful patient selection, monitoring, and prophylaxis are crucial when using anti-TNF-α agents in patients with liver conditions.
Keywords:
adalimumabalcoholic hepatitisautoimmune hepatitiscertolizumab pegoldrug-induced liver injuryetanerceptgolimumabhepatitis B virushepatitis C virusinfliximabnon-alcoholic fatty liver disease

More Related Videos

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC11:38

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

Published on: May 10, 2016

12.8K
The Influence of Liver Resection on Intrahepatic Tumor Growth07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

9.9K

Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.6K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
568
Factors Affecting α-Alkylation of Ketones: Choice of Base01:10

Factors Affecting α-Alkylation of Ketones: Choice of Base

α-Alkylation of ketones is achieved in the presence of alkyl halides and a base. The reaction proceeds via the formation of an enolate ion followed by nucleophilic substitution. The choice of base employed is essential as it is the key factor in determining the reaction outcome.
The reaction involving bases like EtO− whose conjugate acid EtOH (pKa = 15.9) is stronger than the ketone (pKa = 19.2) results in an equilibrium mixture with higher ketone concentration. As a consequence,...
3.6K
Benefits of Self-Esteem01:25

Benefits of Self-Esteem

Self-esteem—an individual's overall evaluation of their worth—plays a complex role in psychological functioning and well-being. It is often associated with many positive traits, such as confidence, optimism, and perseverance. Individuals with high self-esteem typically experience better sleep, manage peer pressure more effectively, and report greater life satisfaction. Conversely, low self-esteem has been consistently linked with increased risks of depression, anxiety, and poor...
205
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.7K
Framing Effects03:26

Framing Effects

Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
8.0K