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Safety of an Oncolytic Myxoma Virus in Dogs with Soft Tissue Sarcoma

Amy L MacNeill1, Kristen M Weishaar2, Bernard Séguin3

  • 1Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA. amy.macneill@colostate.edu.

Viruses
|August 1, 2018
PubMed

Insights

Myxoma virus lacking the serp2 gene (MYXVΔserp2) showed a good safety profile in dogs with soft tissue sarcomas. This oncolytic virus is a promising candidate for further clinical trials in cancer patients.

Area of Science:

  • Oncolytic virotherapy
  • Veterinary oncology
  • Immunology

Background:

  • Many oncolytic viruses effective in mouse models fail in human trials.
  • Canine cancer models offer a more predictive platform for human treatment outcomes.
  • Myxoma virus (MYXV) is a potential oncolytic agent.

Purpose of the Study:

  • To assess the safety of myxoma virus lacking the serp2 gene (MYXVΔserp2) in dogs with spontaneous tumors.
  • To determine the immunogenicity of MYXVΔserp2 in canine patients.
  • To provide safety data for advancing MYXVΔserp2 into clinical trials.

Main Methods:

  • Dogs with spontaneous soft tissue sarcomas received intratumoral or post-operative MYXVΔserp2 treatment.
  • Clinical assessments, tumor biopsies, and swabs were analyzed for viral DNA.
  • Blood, urine, and feces were monitored for organ function, virus distribution, and immune response.

Main Results:

  • No detrimental effects or significant changes in blood profiles, serum chemistry, or urinalysis were observed.
  • Viral DNA was detected in one tumor swab; no systemic viral dissemination occurred.
  • Anti-MYXV antibodies were occasionally detected, indicating an immune response.

Conclusions:

  • MYXVΔserp2 demonstrates a favorable safety profile in dogs with cancer.
  • The study provides essential safety data supporting further clinical investigation of MYXVΔserp2.
  • Oncolytic virotherapy with MYXVΔserp2 shows potential for canine and human cancer treatment.
Keywords:
caninemyxoma virusoncolytic poxvirussarcoma

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