Which evidence for a treat to target strategy in ulcerative colitis?

The main therapeutic goal of in ulcerative colitis is to maintain disease remission. The new concept of deep remission implies also a complete mucosal healing. Histological assessment of disease in UC seems to be an important prognostic factor to predict disease outcome. In this article we review current definitions of mucosal healing, histological healing, histological remission and available histological scores assessing histological activity of disease in ulcerative colitis. Comparison between mucosal healing and histological remission shows that histological remission is a better prognostic factor than mucosal healing to predict outcome in ulcerative colitis and could be a new therapeutic goal in ulcerative colitis but actually histology is not a target due to lack of evidence of clinical utility. Some investigations are needed to clearly defined histological remission and to determine its role in therapeutic strategy. Futhermore histological assessment remains an invasive exploration and other alternative as faecal markers are discuss to predict ulcerative outcome.