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Changes in the choroid plexuses and brain barriers associated with high blood pressure and ageing

I Gonzalez-Marrero1, L G Hernández-Abad2, L Castañeyra-Ruiz3

  • 1Departamento de Anatomía, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, España.

Neurologia
|August 1, 2018
PubMed

Insights

High blood pressure (HBP) alters choroid plexuses and brain barriers, impacting cerebrospinal fluid production and integrity. These changes are more pronounced in the blood-CSF barrier than the blood-brain barrier.

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Cerebrospinal Fluid Dynamics

Background:

  • Choroid plexuses (ChP), blood vessels, and brain barriers share intricate morphological and functional relationships.
  • Hypertension (HBP) significantly impacts cerebral blood flow, small brain vessels, and capillaries.
  • This review examines the specific effects of HBP on the choroid plexuses and brain barrier systems.

Purpose of the Study:

  • To investigate the impact of high blood pressure (HBP) on choroid plexuses (ChP) and brain barriers.
  • To understand how HBP-induced vascular changes affect ChP function and cerebrospinal fluid (CSF) production.
  • To compare the effects of HBP on the blood-brain barrier (BBB) and the blood-CSF barrier (BCSFB).

Main Methods:

  • Review of existing literature on choroid plexuses, brain barriers, and hypertension.
  • Analysis of the structural and functional components of the ChP and their role in CSF production.
  • Examination of the mechanisms by which chronic hypertension induces vascular remodeling and affects brain circulation.

Main Results:

  • High blood pressure induces significant changes in choroid plexus stroma, vasculature, and cerebrospinal fluid production.
  • HBP exacerbates age-related dysfunction in the choroid plexuses.
  • Alterations in brain barriers are observed, with more pronounced effects on the blood-CSF barrier compared to the blood-brain barrier.

Conclusions:

  • High blood pressure detrimentally affects choroid plexus structure and function, influencing CSF dynamics.
  • The blood-CSF barrier is more susceptible to damage from HBP than the blood-brain barrier.
  • Blood levels of S-100β and TTRm can serve as biomarkers for assessing brain barrier damage induced by HBP.
Abstract

Keywords:
AgingBarreras cerebralesBrain barriersChoroid plexusesEnvejecimientoHipertensiónHypertensionPlexos coroideos

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