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Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
Published on: September 13, 2014
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Acute liver failure secondary to ABVD use
Amir Eslami1, Anupama Divakaruni Mathur2, Kunal Kishor Jha1
1Department of Internal Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA.
BMJ Case Reports
|August 1, 2018
Summary
A rare case of acute liver failure occurred in a 79-year-old woman undergoing advanced Hodgkin
Area of Science:
- Oncology
- Hepatology
- Internal Medicine
Background:
- Hodgkin's lymphoma (HL) is a lymph node cancer.
- Advanced HL treatment commonly uses doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy.
- ABVD is generally safe, with rare reports of acute liver failure.
Observation:
- A 79-year-old woman with advanced HL received the first cycle of ABVD chemotherapy.
- The patient developed acute liver failure following the initial ABVD cycle.
Findings:
- This case highlights a rare instance of acute liver failure potentially linked to ABVD chemotherapy in an elderly patient.
- The patient's presentation suggests a possible idiosyncratic reaction to ABVD, leading to severe hepatotoxicity.
Implications:
- Clinicians should consider the risk of acute liver failure when administering ABVD chemotherapy, especially in elderly patients.
- Further investigation into the mechanisms of ABVD-induced hepatotoxicity may be warranted.
- Monitoring liver function is crucial during ABVD treatment for advanced Hodgkin's lymphoma.
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