Related Experiment Video
Updated: Feb 7, 2026

In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines
Published on: March 5, 2019
LINC00675 is a prognostic factor and regulates cell proliferation, migration and invasion in glioma
Zhibing Li1, Yijian Li2, Qibai Wang3
1Department of Neurology, Shanxi Provincial Tumor Hospital, Taiyuan 030003, Shanxi, China.
Abstract:
LINC00675 has been suggested to be dysregulated in gastric cancer, colorectal cancer and pancreatic cancer. However, the expression status and biological function of LINC00675 in glioma were still unknown. Thus, we reported LINC00675 was overexpressed in glioma tissues and cell lines, and positively associated with advanced WHO grade, large tumor size and poor prognosis. Moreover, univariate and multivariate analyses suggested that high-expression of LINC00675 was an independent unfavorable prognostic predictor for glioma. In addition, levels of LINC00675 expression were positively correlated with TRIP6 mRNA and protein expressions. The in vitro experiment showed that silencing of LINC00675 inhibits glioma cell proliferation, migration and invasion through regulating TRIP6. In conclusion, LINC00675 acts as a tumor promoter in glioma progression.
Related Concept Videos
Cell Migration
Cell Migration
Cells Coordinate Growth and Proliferation
Transcription Factors
Epigenetic Regulation
pH Regulation in Cells
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...

